EdenteV2, France, Analysis, bibRecord, 000502

Immune cell defects affect bone remodelling in osteopetrotic op/op mice

Identifieur interne : 000502 ( France/Analysis ); précédent : 000501; suivant : 000503

Immune cell defects affect bone remodelling in osteopetrotic op/op mice

Auteurs : C. Philippart [France] ; E. Tzehoval [Israël] ; Y. Moricard [France] ; A.-F. Bringuier [France] ; C. Seebold [France] ; F.-M. Lemoine [France] ; A. Arys [Belgique] ; N. Dourov [Belgique] ; M.-L. Labat [France]

Source :

Bone and Mineral [ 0169-6009 ] ; 1993.

RBID : ISTEX:4A0D11A0C4802218FC67BFACA654F7E7046D7F5B

Descripteurs français

Wicri :
- topic : Sciences de la vie, Mineur (ouvrier).

English descriptors

Abstract

Abstract: The aim of the present work was to further characterize immunological defects in osteopetrosis. The op/op mutant mouse is of particular interest since a marrow cavity develops spontaneously in older animals. The interleukin production (IL-1, IL-2, IL-3, IL-4, IL-6), the presence of macrophage differentiation antigens and the evolution of the bone lesions were studied in osteopetrotic and normal mice. Low levels of IL-1, IL-3 and IL-4 were observed at the age of 6 weeks in the op/op mice. However, at 22 weeks of age, the level of IL-1 and IL-4 returned to normal value in these op/op mice whereas the level of IL-3 remained partially decreased at the same age. Furthermore, macrophage expression of MAC-2 antigen, reduced at 12 weeks of age was found to be normal 10 weeks later. These immunological defects and their recovery seems to be concomitant with the healing of the bone lesions.

Url:

https://api.istex.fr/document/4A0D11A0C4802218FC67BFACA654F7E7046D7F5B/fulltext/pdf

DOI: 10.1016/S0169-6009(08)80106-7

Affiliations:

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ISTEX:4A0D11A0C4802218FC67BFACA654F7E7046D7F5B

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Average number</term>
<term>Bone lesions</term>
<term>Bone marrow</term>
<term>Bone marrow cells</term>
<term>Bone miner</term>
<term>Bone remodelling</term>
<term>Bone resorption</term>
<term>Coding region</term>
<term>Ctll indicator cells</term>
<term>Culture media</term>
<term>Culture medium</term>
<term>Cultured osteoblasts</term>
<term>Cytokine</term>
<term>Cytoplasmic vacuoles</term>
<term>Different ages</term>
<term>Electron microscopy</term>
<term>Histologic examination</term>
<term>Human marrow stromal cells</term>
<term>Immunological defects</term>
<term>Indicator cells</term>
<term>Indicator line</term>
<term>Interleukin</term>
<term>Interleukin secretions</term>
<term>Interleukins</term>
<term>Lesion</term>
<term>Life sciences</term>
<term>Light microscopy</term>
<term>Littermates</term>
<term>Long bones</term>
<term>Macrophage</term>
<term>Macrophage colony</term>
<term>Macrophage differentiation antigens</term>
<term>Macrophages</term>
<term>Marrow cavity</term>
<term>Miner</term>
<term>Monoclonal antibodies</term>
<term>Mouse</term>
<term>Mutant</term>
<term>Mutant mice</term>
<term>Normal levels</term>
<term>Normal littermates</term>
<term>Normal mice</term>
<term>Normal mouse</term>
<term>Older mutants</term>
<term>Osteoclast</term>
<term>Osteopetrosis</term>
<term>Osteopetrotic</term>
<term>Osteopetrotic bone lesions</term>
<term>Osteopetrotic mice</term>
<term>Osteopetrotic mouse</term>
<term>Other hand</term>
<term>Partial bone resorption</term>
<term>Peritoneal macrophages</term>
<term>Philippart</term>
<term>Pluripotent hemopoietic</term>
<term>Present work</term>
<term>Proc natl acad</term>
<term>Radiolucent diaphysis</term>
<term>Resorption</term>
<term>Several triplicated dilutions</term>
<term>Spleen</term>
<term>Spleen cells</term>
<term>Supernatant</term>
<term>Thioglycollate broth</term>
<term>Triplicate cultures</term>
<term>Tritiated thymidine</term>
<term>Viable cells</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Average number</term>
<term>Bone lesions</term>
<term>Bone marrow</term>
<term>Bone marrow cells</term>
<term>Bone miner</term>
<term>Bone remodelling</term>
<term>Bone resorption</term>
<term>Coding region</term>
<term>Ctll indicator cells</term>
<term>Culture media</term>
<term>Culture medium</term>
<term>Cultured osteoblasts</term>
<term>Cytokine</term>
<term>Cytoplasmic vacuoles</term>
<term>Different ages</term>
<term>Electron microscopy</term>
<term>Histologic examination</term>
<term>Human marrow stromal cells</term>
<term>Immunological defects</term>
<term>Indicator cells</term>
<term>Indicator line</term>
<term>Interleukin</term>
<term>Interleukin secretions</term>
<term>Lesion</term>
<term>Life sciences</term>
<term>Light microscopy</term>
<term>Littermates</term>
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<term>Macrophage colony</term>
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<term>Marrow cavity</term>
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<term>Mutant mice</term>
<term>Normal levels</term>
<term>Normal littermates</term>
<term>Normal mice</term>
<term>Normal mouse</term>
<term>Older mutants</term>
<term>Osteoclast</term>
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<term>Osteopetrotic</term>
<term>Osteopetrotic bone lesions</term>
<term>Osteopetrotic mice</term>
<term>Osteopetrotic mouse</term>
<term>Other hand</term>
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<term>Peritoneal macrophages</term>
<term>Philippart</term>
<term>Pluripotent hemopoietic</term>
<term>Present work</term>
<term>Proc natl acad</term>
<term>Radiolucent diaphysis</term>
<term>Resorption</term>
<term>Several triplicated dilutions</term>
<term>Spleen</term>
<term>Spleen cells</term>
<term>Supernatant</term>
<term>Thioglycollate broth</term>
<term>Triplicate cultures</term>
<term>Tritiated thymidine</term>
<term>Viable cells</term>
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<front><div type="abstract" xml:lang="en">Abstract: The aim of the present work was to further characterize immunological defects in osteopetrosis. The op/op mutant mouse is of particular interest since a marrow cavity develops spontaneously in older animals. The interleukin production (IL-1, IL-2, IL-3, IL-4, IL-6), the presence of macrophage differentiation antigens and the evolution of the bone lesions were studied in osteopetrotic and normal mice. Low levels of IL-1, IL-3 and IL-4 were observed at the age of 6 weeks in the op/op mice. However, at 22 weeks of age, the level of IL-1 and IL-4 returned to normal value in these op/op mice whereas the level of IL-3 remained partially decreased at the same age. Furthermore, macrophage expression of MAC-2 antigen, reduced at 12 weeks of age was found to be normal 10 weeks later. These immunological defects and their recovery seems to be concomitant with the healing of the bone lesions.</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
<li>Israël</li>
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<li>Île-de-France</li>
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<tree><country name="France"><region name="Île-de-France"><name sortKey="Philippart, C" sort="Philippart, C" uniqKey="Philippart C" first="C." last="Philippart">C. Philippart</name>
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<name sortKey="Bringuier, A F" sort="Bringuier, A F" uniqKey="Bringuier A" first="A.-F." last="Bringuier">A.-F. Bringuier</name>
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<name sortKey="Lemoine, F M" sort="Lemoine, F M" uniqKey="Lemoine F" first="F.-M." last="Lemoine">F.-M. Lemoine</name>
<name sortKey="Moricard, Y" sort="Moricard, Y" uniqKey="Moricard Y" first="Y." last="Moricard">Y. Moricard</name>
<name sortKey="Seebold, C" sort="Seebold, C" uniqKey="Seebold C" first="C." last="Seebold">C. Seebold</name>
</country>
<country name="Israël"><noRegion><name sortKey="Tzehoval, E" sort="Tzehoval, E" uniqKey="Tzehoval E" first="E." last="Tzehoval">E. Tzehoval</name>
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<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Arys, A" sort="Arys, A" uniqKey="Arys A" first="A." last="Arys">A. Arys</name>
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<name sortKey="Dourov, N" sort="Dourov, N" uniqKey="Dourov N" first="N." last="Dourov">N. Dourov</name>
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Immune cell defects affect bone remodelling in osteopetrotic op/op mice

Immune cell defects affect bone remodelling in osteopetrotic op/op mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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